Ampicillin

Ampicillin (Principen)

Brand Name: Principen

Ampicillin is an antibiotic belonging to the polysynthetic penicillin group. He has a great functional field and has an antimicrobial effect by suppressing the synthesis of microorganism cell wall.

This medicine is efficient in relation to gram-positive aerobic microorganisms: staphylococcus (excluding strains forming penicillinase), streptococcus (including Enterococcus), Listeria, gram-negative aerobic microbes: Neisseria meningitidis, Escherichia coli, Shigella, Salmonella, Bordetella pertussis, some microorganisms Haemophilus influenzae. Ampicillin is disintegrated under the penicillinase influence, and it is an acid-resistant.

It’s important to say that if you take the drug orally it is perfectly absorbed from the gastroenteric tract, not being destroyed in the acid environment. But taking it intramuscularly or intravenously it is in the blood plasma in high concentration.

The drug enters the tissue and body fluids, and is in adequate concentrations in the vaginal, peritoneal and synovial fluids. Ampicillin gets to amniotic fluid through placenta during pregnancy. Unfortunately this medicine badly passes hematoencephalic barrier (HEB), but during inflammatory processes of brain fever the penetrance of hematoencephalic barrier is strongly increased. About 30% of the drug is remained in the liver in the metabolites form. Ampicillin is mainly excreted out of the body through the kidneys, along with urine or with gall.